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16 Philan T hro P y i n a CT ion Gastrointestinal Cancer Research THE NEED for OncoSET for People with GI Cancers We recognize the desperate need for new medical discoveries to provide better options for people challenged with very difficult and complex gastrointestinal (GI) cancers, such as liver, pancreatic, and colon cancers. This year, there will be an estimated 1.7 million new cancer cases and over 595,000 deaths. Of this total, GI cancers will account for nearly 20% of cancer cases. For over 18 years, we have chosen to partner with the world-class Robert H. Lurie Comprehensive Cancer Center of Northwestern University to advance this urgent cause in significant ways. THE POWER to Deliver Personalized Therapies OncoSET is driven by three vital steps: • Sequence to determine the makeup of a tumor using genomic analysis • Evaluate and discuss the genetic profile with the Lurie Cancer Center's OncoSET Molecular Tumor Board, a multidisciplinary group of leading physicians and scientists • Treat based on a personalized plan, with a targeted therapy or a new treatment being studied in a clinical trial These steps are complemented by important laboratory research studies that will be developed using molecular information and may ultimately lead to the development of novel therapeutic agents. Our commitment to fund and name the GI Cancer OncoSET program at Northwestern will specifically help to advance the development of new novel clinical trials in GI cancers, as well as crucial translational (bench-to- bedside) research and genomic profiling activities. Oncology Personalized Cancer Medicine + Molecular Analysis = We have committed $1.5 million towards transforming the field of cancer care and research through precision medicine. The OncoSET program is an unprecedented initiative to deliver personalized treatment to patients with very limited options. We believe in the enormous potential of this investment to accelerate the future of cancer medicine. Our $1.5M Gift to Pioneer Precision Cancer Medicine Announcing the Harold E. Eisenberg Foundation GI Cancer OncoSET Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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